Comaneci is active in many charities and international organizations. In 1999, she became the first athlete to be invited to speak at the United Nations to launch the Year 2000 International Year of Volunteers. She is currently the Vice-Chair of the Board Of Directors of the International Special Olympics and Vice President of the Board of Directors of the Muscular Dystrophy Association. She has also personally funded the construction and operation of the Nadia Comaneci Children's Clinic, a clinic in Bucharest that provides low-cost and free medical and social support to Romanian children.
In 2003, the Romanian government appointed her as an Honorary Consul General of Romania to the United States to deal with bilateral relations between the two nations. She performs this function based out of her Norman, Oklahoma, office.
In the world of gymnastics, Comaneci is the Honorary President of the Romanian Gymnastics Federation, the Honorary President of Romanian Olympic Committee, Ambassador of Sports of Romania and a member of the International Gymnastics Federation Foundation. She and her husband own the Bart Conner Gymnastics Academy, the Perfect 10 Production Company and several sports equipment shops. They are also the editors of International Gymnast magazine. Additionally, Comaneci and Conner have provided television commentary for many gymnastics meets, most recently the 2005 World Championships in Melbourne and the 2008 Olympic Games in Beijing. In 2004, her 10.0 Montreal uneven bars routine was featured in a commercial for Adidas which ran during the Athens Olympics.
On August 10, 2007, Nadia was a "mob" participant on the American version of the game show 1 vs 100, and was not eliminated until the last 20 members of the mob were left. In January 2008, she was one of the contestants in the celebrity edition of Donald Trump's television program The Apprentice.